Cystic fibrosis is a common autosomal recessive genetic condition with a frequency in the United States of 1 in 3300. 85% of CF affected patients accumulate thick mucus in their lungs and pancreas causing difficulties with breathing and digestion, while 15% experience only lung problems. Milder conditions also associated with CF include male infertility (due to the congenital absence of vas deferens) and pancreatitis. Indications for CF genetic testing include:

• Pregnant woman
• Reproductive partner of a known CF carrier
• Preconception couple, sperm or egg donor
• Prenatal diagnosis for CF carrier couple or couple with a previously-affected child
• Male with congenital absence of the vas deferens (DBAVD) and his partner
• Individual with a family history of CF, or symptomatic individual
• Fetal echogenic bowel on ultrasound